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Ipamorelins anti-apoptotic actions in hepatocytes have been characterised in several injury contexts: In Fas-mediated (Jo2 anti-Fas antibody 0.5g/g i.p.) apoptosis models, ipamorelin pre-treatment reduces caspase-8 p18 and Bid cleavage to tBid (truncated Bid, the cross-talk amplifier between extrinsic and intrinsic pathways), and limits caspase-3 p17 active fragment and PARP-1 89kDa cleavage product detected by western blot from hepatic lysates

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