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In the context of substance use disorders, additional safety considerations emerge

Although how exactly these drugs help in weight loss is not known, as GLP-1 agonists slow the movement of food traveling from the stomach to the small intestine, it makes people feel full quicker and for longer, and so, it is thought to boost weight loss because people tend to eat less as result of the medication

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GLP-1 medications must be discontinued at least 2 months before planned pregnancy

Then, the media were discarded, and the cells were washed by PBS then the metabolites extracted using methanol: water (9:1, v/v) mixtures

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