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Further, the authors found that reduced GLP-1+ cells in mice and inhibition of respiration in organoid cultures support a causative role for metabolism in steering differentiation

They may have varying effects and side effects in different individuals

Aravinda S, Gopalakrishnan B, Dey CS et al (1995) A testicular protein important for fertility has glutathione S-transferase activity and is localized extracellularly in the seminiferous tubules