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The elevation in maternal FFA levels intensifies insulin resistance by impairing glucose uptake and promoting hepatic gluconeogenesis [6]

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As a natural pharmaceutical ingredient, berberine has the advantage of high safety (Rabbani et al., 1987), it is generally considered to be non-genotoxic and cytotoxic in clinical (Imanshahidi and Hosseinzadeh, 2008)

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