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Elevated choline kinase alpha-mediated choline metabolism supports the prolonged survival of TRAF3-deficient B lymphocytes
However, analysis of trial data from five long-acting GLP-1 agonists (exenatide once weekly, taspoglutide, albiglutide, LY2189265 and CJC-1134-PC) revealed that they were more likely than shorter-acting formulations to raise the heart rate (Robinson et al., 2013)
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The earlier RCT showed no significant effect of exenatide on alcohol consumption in people with AUD, although a secondary analysis indicated reduced alcohol intake in the subgroup with AUD and comorbid obesity [71]
I dont know for certain but while Lilly and Novo made these GLPs 1x weekly for compliance purposes and relied on the long half life, twice weekly makes more sense in terms of AUC, CMax and avoiding peaks as well as uncomfortable effects
Particularly active in localised tissue repair and GI cytoprotection
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