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It primarily interacts with GLP-1,

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This establishes the central role of PGC-1 in coordinating mitochondrial energy production and antioxidant balance

In mouse models of myocardial ischemiareperfusion, substantial ferritin accumulation along the scar areas indicates that excess iron can lead to cardiomyocyte death through ferroptosis [200]

When semaglutide or tirzepatide degrades, the active compound breaks down into inactive fragments