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The angiopep-2 peptide that binds to low-density lipoprotein receptor-related protein-1 (LRP-1) was conjugated to paclitaxel via a succinyl group (named ANG1005) and applied to the treatment of glioma and metastatic breast cancer 82
Johnson and Bobrovskaya, 2015)
doi 10.1016/s0016-5085(76)80163-1 110 MigliorisiGGabbiadiniRDal BuonoAFerrarisMPriviteraGPetronioLet al
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It is believed to work centrally in the brain rather than peripherally in the tissues
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