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Clinical trials demonstrate that probiotics can alleviate depressive symptoms by modulating the gut microbiome

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Diarrhea: Occured in 28.3% of patients on semaglutide in the STEP-1 trial, compared to 12.4% in the placebo group

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Metformin has also been associated with undesired side-effects, as gastrointestinal distress, and has modest effects on body weight in women with PCOS and obesity 25

Published research has employed this analog to study myoblast differentiation, satellite cell activation, and skeletal muscle hypertrophy signaling in C2C12 cultures, as well as hepatocyte glucose uptake via GLUT4 translocation