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Yes, Hypochlorous Acid affects Tretinoin absorption and effectiveness through the influence on skin pH and barrier integrity

For bulk RNA-seq data, we used the ssGSEA algorithm (the gsva function from the GSVA package v1.44.2) to integrate gene signatures and calculate the signature score for each sample

Regulation of gene expression modulates the activity of genes related to DNA repair, metabolism, and inflammatory processes

The article says major diabetes trials prioritize monotherapy or the stepwise addition of non-incretin agents over dual-incretin combinations, and it frames the cost and complexity of doubling up on incretins as unjustified by the clinical gain

Literature context belongs in the background section

Additional tests like blood tests and biopsies may be needed