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While some initial effects, such as reduced appetite, may be noticeable within the first few weeks as the dosage is gradually increased, significant and consistent weight loss generally becomes evident over several months of treatment

They said that compounded medications could contain contaminants, or dosing could vary quite a bit from that of name-brand medications and potentially be less effective

This newly charted pathway - separate from previously described mechanisms that broadly affect appetite - could be an avenue by which GLP-1s treat other dysfunctions in reward processing, such as substance use disorder