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For example, a similar study conducted by Huang et al

The eMTD peptide (KLNFRQKLLNLISKLFCSGT), consisting of the BH3 domain and mitochondrial targeting domain of the Noxa protein, causes cell membrane damage and necrotic cell death by interacting with voltage-dependent anion channel 2 63

There were also downregulations observed in subunits of oxidative phosphorylation enzymes, but these were counterbalanced by concurrent significant upregulations in other subunits

Riboflavin is also important in the metabolism of iron

For some people, the effect is meaningful