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Cebrin, J., Messeguer, A., Facino, R

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Additionally, the specific deletion of SIRT6 leads to the activation of the Notch1/Jagged1 (Jagged1 is a ligand in the Notch signaling pathway, which activates the Notch signaling pathway by binding to the Notch receptor) signaling pathway, exacerbating the inflammatory response and autophagic damage of podocytes in the HG-treated podocytes