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5 Insulin resistance is believed to be a crucial underlying mechanism that links these two diseases

Preoperative and postoperative nutritional support is essential, particularly ensuring adequate weight-based protein intake for 24 weeks before surgery and continuing for at least 4 weeks postoperatively to support optimal healing [93]

These are weekly injections at low volumes

Study B, employing a crossover design, demonstrated that twice-daily PT-141 administration resulted in greater mean body weight reduction (1.7 kg) versus placebo (0.9 kg)