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Kumar et al., 2009) characterized by polydipsia (increased thirst), polyuria (frequent urination), and polyphagia (increased hunger) with consequences of homeostasis disruption because of impaired glucose metabolism

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doi: 10.1158/2326-6066.CIR-18-0243 35 DornerMBrandtSTinguelyMZucolFBourquinJPZaunerLet al

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Continuous use increases side effect risk and promotes desensitization

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