Approximately 80 to 150 cases of upper gastrointestinal bleeding, which usually leads to melena, has taken place in every 100,000 individuals every year, globally
GopinathGSankeshiVperuguSAlaparthiMDBandaruSPasalaVKet al
Animal research using mice was conducted under a protocol approved by the UC Irvine Institutional Animal Care and Use Committee (IACUC) in compliance with the Animal Welfare Act and other federal statutes relating to animals and experiments using animals (Burke lab animal use protocol AUP-22-005 and AUP-25-004)
While these medications had impactful weight loss outcomes, with mean weight reduction in trials ranging from 7 to 10% [3,4,5], they lacked substantial evidence of improvement in cardiovascular outcomes
doi: 10.1038/s41467-020-16890-6
GLP-1 acts on various body tissues to maintain normal glucose metabolism and manage body weight without the risk of hypoglycemia