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Glioma Stem-like cells (GSCs) are Cancer initiating cells (CICs) maintaining self-renewal properties, sustaining cellular hierarchy, and partially explaining the tumor heterogeneity since they maintain a progeny responsible for tumor complexity ( + cells able to initiate new tumors in mice ( According to the most recent World Health Organization for Glioma classification, GBM is labeled as a grade IV glioma (Figure 1), it may be classified into two types depending on its severity: primary and secondary GBM

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