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Brain Insulin Resistance: The Type 3 Diabetes Hypothesis Alzheimers brains exhibit reduced insulin receptor expression and impaired signaling, disrupting glucose metabolism and contributing to tau phosphorylation, amyloid clearance deficits, and synaptic dysfunction

K., Liu, B., Cui, X., Brown, K., & SURPASS-2 Investigators (2021)

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Secondary descriptive measures included therapy duration, ending dose strength, number of weight measurements, and availability of post-therapy follow-up