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This discrepancy is probably due to the CKD-associated GH insensitivity of the kidneys, preventing GH actions on the glomerular cells and/or the considerably lower GH exposure in rhGH-treated patients, compared to GH excess in acromegalic patients and GH transgenic animals

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Disrupting the FOXO4-p53 interaction induces p53 nuclear exclusion, leading to apoptosis in senescent cells while sparing healthy ones

Enhanced Recovery GH promotes cell repair , collagen production , and mitochondrial biogenesis , helping the body bounce back from physical exertion, illness, or injury more quickly

doi: 10.1002/biof.1401

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