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Public Health 10 , 176 (2022)

The authors show that prolonged exposure of insulin-secreting cells and isolated mouse islets to elevated levels of the fatty acid palmitate leads to decreased Glp1r expression, impaired incretin potentiation of glucose-stimulated insulin secretion and diminished GLP-1 signalling [4]

[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Darpo B, Zhou M, Matthews J, Zhi H, Young MA, Perry C, Reinhardt RR