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In contrast, excessive formation of ROS is responsible for disrupted redox homeostasis which in turn leads to oxidative stress and ROS-mediated damage to all important biomolecules including DNA, proteins, and membranes (Liguori et al
Hemokinin-1 Is an Important Mediator of Endotoxin-Induced Acute Airway Inflammation in the Mouse
This disruption allows inflammatory mediators and immune cells to pass into the brain, perpetuating the neuroinflammatory cycle associated with depression [191]
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SpencerJPAbd El MohsenMMMinihaneA-MMathersJC
Importantly, blockade of cysteine-dependent glutathione synthesis was sufficient to reverse melatonin-mediated suppression of ILC2 cytokine production ( Figures 6J, K )
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