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Semaglutide toxicity typically manifests through gastrointestinal distress rather than organ-level poisoning

Clinical criteria require a documented diagnosis of obesity (BMI 95th percentile for age and sex, or BMI 30 kg/m at age 17+) plus at least one weight-related comorbidity, such as type 2 diabetes, prediabetes, hypertension, or dyslipidemia

10.2105/AJPH.2016.303326 5

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Multiple lipid species were decreased in both surgical groups at 30 minutes, consistent with postprandial rises in insulin secretion