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Important Safety Information for Foundayo (orforglipron) tablet Warning: Risk of Thyroid C-Cell Tumors In rats and mice, certain GLP-1 medications caused thyroid C-cell tumors

Control groups consisting of five animals each were also included, where formulations were tested in which the active was absent (exenatide study), or in which the vehicle contained active, but propyl gallate was omitted from the formulation (semaglutide)

Thus, individuals taking methotrexate may have an increased choline requirement

doi:10.3389/fendo.2025.1568438

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