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Int Rev Neurobiol 349371 El Yacoubi MLC, Parmentier M, Bertorelli R, Ongini E, Costentin J, Vaugeois JM (2001) Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice

doi:10.1038/s41430-018-0348-y [30] Vondra K, Vrbikova J, Dvorakova K

Cherix A, et al

Elevated ROS, in turn, activate the Nrf2 transcription factor, upregulating CES1 expression and enzyme activity, thereby forming the NOX/ROS/Nrf2/CES1 signaling axis, which constitutes a self-amplifying oxidative stress cascade (Ge et al., 2023)

PloS One

Within minutes of the infusion, the patients reportedly experienced symptoms of varying degrees, including nausea, vomiting, lightheadedness, chills, body aches and sneezing