A molecules effect depends not only on its intrinsic biology but on where it goes, how much of it reaches the target tissue, how long it persists, and what else it interacts with along the way
The overwhelming dominance of ROS generated by enzymes like NADPH oxidases and xanthine oxidase over antioxidants like superoxide dismutase causes cell injury and tissue damage through direct injury, lipid peroxidation and protein oxidation leading to protease release and antioxidant and antiprotease enzyme inactivation as well as alteration of transcription factors activator protein-1 and NFB
And when weight loss finally starts happening through another mechanism like appetite suppression from a medication, something interesting can happen
Florou P, Anagnostis P, Theocharis P, Chourdakis M, Goulis DG
Vitamins E and C in the prevention of prostate total cancer in men: the physicians' health study II randomised controlled trial
it accounts for more than 90% of the cases (2)