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Lidocaine might lead to methemoglobinemia and it has to be treated as soon as possible

Tanaka C, Coling DE, Manohar S, Chen GD, Hu BH, Salvi R, Henderson D

Placebo-controlled pilot trial testing dose titration and intravenous, intramuscular and subcutaneous routes for ketamine in depression

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Analogues 1 and 2 exhibited superior potency (IC 50 = 0.30 and 0.94 M, respectively), up to 90 times more selective for AKR1C3 over AKR1C2, and demonstrated higher efficacy than indomethacin without off-target effects on AKR1C2 and COX1/2 ( 6.1.3 N-phenylanthranilic acids Among the compounds explored as AKR1C3 inhibitors, Flufenamic acid (FLU), a sort of NSAIDs, has demonstrated potent inhibition of AKR1C3 activity (IC 50 = 8.63 M)