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While insulin resistance per se which allows glucose levels in the blood to rise to dangerous levels hasnt been found in chronic fatigue syndrome (ME/CFS), an exercise-related insulin resistance which was ameliorated by metformin did show up in cultured muscle cells from ME/CFS patients

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HCG and Hyperglycosylated Isoform Research Hyperglycosylated hCG (hCG-H) is an over-glycosylated isoform of hCG that comprises up to 90% of total hCG measurable in serum and urine during the first 23 weeks of pregnancy when invasive trophoblast activity is at its highest dropping to less than 5% of total hCG by the end of the first trimester