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Moreover, IGFBP-1 inhibition in cancer cells also blocked angiogenesis in HUVECs treated with conditioned medium (42)

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Clearly, the concurrency of these factors in the presence of high amounts of polyunsaturated fatty acids, mainly DHA, is expected to favor the free radical-induced peroxidation of DHA in the brain parenchyma (Van Kuijk et al., 1990