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Mitochondrial and cytoplasmic ROS have opposing effects on lifespan

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Translational Gap: Critical

While the haem biosynthesis and degradation pathway has already been demonstrated to be synthetic lethal in FH-deficient cells, the role of GSH metabolism in FH-deficient cells has not been investigated before and required further investigation

This technology can also be used to temporarily open blood-brain-barrier (along with microbubble techniques) to deliver neuroprotective agents and other medications directly to brain tissue (3b) (3c) (3d) (3e) (3f) (3g) (3h)