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Both 1/ values were similar to the corresponding apparent catalytic efficiencies and decreased for K105X mutants by up to one or two orders of magnitude (Fig

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CACNA1G-AS1 impedes ferroptosis in ovarian cancer cells and fosters the malignant phenotype of cells through IGF2BP1-FTH1-mediated ferroautophagy, thereby presenting a novel biomarker and therapeutic target for the clinical assessment of ovarian cancer patients ( 3.3 Immunotherapy and ferroptosis Despite the persistent endeavors of scholars to investigate treatment strategies for ovarian cancer, the available options for treatment remain limited, with high rates of recurrence and chemotherapy resistance

Frontiers in Nutrition, 7 , 606124

However, ethical considerations, external validity limitations, challenges in double-blinding, and interference from internal and external factors, coupled with inadequate statistical power and significant financial/temporal requirements, have hampered the feasibility of conducting RCTs