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FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells

GLP-1 based medicines (including newer combination therapies that activate GLP-1 plus other gut hormone receptors) are used for type 2 diabetes, heart disease, and weight management

The liver enzyme pattern is noteworthy because retatrutide simultaneously shows potent fat-clearing effects in the liver (beneficial for MASLD/NAFLD) while occasionally triggering transient enzyme elevations

This increases the risk of hyperuricemia, which can lead to gout

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