doi: 10.1016/j.isci.2025.112464
More than 99% of Thai citizens are covered by one of these schemes
doi:10.2147/DMSO.S106087 Csiszar A, Tarantini S, Yabluchanskiy A, et al
Every patient receives individualized dosing guidance and can adjust their medication regimen as tolerance and goals evolve
Here, acid phosphatase PhoN from Shigella flexneri (PhoN-Sf) was introduced to the system instead of GK and YqaB, which catalyzed the phosphorylation reaction of glycerol in the first step and helped recycle the phosphate of ketose-1-phosphate in the last step to provide free rare-sugar molecules
These findings demonstrate that this class of covalent small-molecule degraderswhile mechanistically distinct from conventional PROTACscan achieve excellent cellular durability with significantly faster kinetics, suggesting favorable drug-like properties