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Inflammation is thought to incite carcinogenesis by causing cell and genome damage, promoting cellular turnover, and creating a tissue microenvironment that can enhance cell replication, angiogenesis and tissue repair

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[DOI] [PubMed] [Google Scholar] Xie T, Chen M, Zhang QH, Ma Z, Weinstein LS

In conventional preclinical rodent studies, gross lesions must be correlated with the histopathological findings

In one study, among patients with non-small cell lung cancer treated with anti-PD-1/PD-L1, those who received corticosteroids to manage their irAE had reduced clinical benefit from immunotherapy, with shorter progression-free survival and overall survival

Furthermore, there are 4 studies about gallic acid, 2 about Edavarone, 3 about crocin and safranal and 7 studies about quercetin, one of them in combination with oleic acid (Table 2)