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The hormone stimulates glucose-dependent insulin secretion from pancreatic beta cells, meaning insulin release occurs only when blood glucose levels are elevated

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The excess floods the pituitary with GHRH signal, leading to receptor desensitization within days rather than months

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Standard gels run glucose only, capping absorption at around 60g per hour

Managing Dosing and Time Zones Crossing time zones can complicate your dosing schedule, but most GLP-1 medications offer a degree of flexibility