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These DAMPs can be sensed by microglia, triggering the cGASSTING pathway and promoting the release of pro-inflammatory cytokines including TNF- and IL-1, which may drive adjacent cells into a ferroptotic state (Gao et al., 2023

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doi: 10.1016/j.dsx.2020.07.013 37

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Such studies may shed light on the underlying causes of melanocyte destruction and pave the way for interventions that prevent melanocyte degeneration and allow for long-lasting repigmentation, an important therapeutic target in vitiligo treatment

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