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Additionally, we demonstrated that HIF-1 acts upstream of receptor-mediated mitophagy, based on our findings that loss of HIF-1 functionachieved through either pharmacological inhibition (PX-478) or genetic downregulationmarkedly suppressed BNIP3/NIX-mediated mitophagy

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These robust results establish a solid foundation upon which adjunctive therapies like L-carnitine may build (Jastreboff et al., 2022)