By Nqobile Dludla JOHANNESBURG, July 21 (Reuters) - South Africa's health regulator is reviewing 12 applications for generic versions of semaglutide, the active ingredient in Novo Nordisk's blockbuster diabetes and weight-loss medicines, it said on Tuesday

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Multiple dose groups were evaluated, giving a picture of how the medication performs across a range of intensities
The safety profile of semaglutide 2.4 mg in STEP 5 was consistent with that in other STEP program trials 6,7,9,16,23 , and with the GLP-1 receptor agonist class in general 28
Additional warnings include the risks of pancreatitis, diabetic retinopathy, hypoglycemia, kidney injury, gallbladder disease, stomach paralysis, severe vomiting and mental health effects such as depression and suicidal ideation
Your immune system, which is highly sensitive to unfamiliar protein shapes, may mount a response