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Despite the widespread use of serotonergic medications, benzodiazepines and cognitive behavioral therapy (CBT), therapeutic outcomes remain limited with less than 50% of patients reaching full remission and nearly one-third do not respond to conventional treatments (De Vries et al., 2016)

In a study on rats, DSIP demonstrated an analgesic effect, increasing the threshold for pain response (Gyermek et al., 1981)

This property makes native GLP-1 an important reference point in comparative studies with its long-acting analogues

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Circ Res 2001

In addition, LA has a number of advantages (widely available in foods, easy to supplement and relatively safe) that help to justify the hypothesis mentioned above