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These data align with an integrated analysis of 36 clinical studies that affirmed cardiovascular safety with up to 4-years treatment with either DPP-4 inhibitors or GLP-1R agonists [655]

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In in vitro skin permeation studies, the cumulative skin permeation of SIN in the optimized TFSs3 formulation was 1.5 times higher than DTFS and 3 times higher than conventional liposomes

The interaction between treatment effect and diabetes duration was not significant for any of the analyzed endpoints

Chondrocytes were passaged at 8090% confluency