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The following side effects (with their frequencies) were reported by participants taking Rybelsus: Nausea (11%) Abdominal pain (10%) Diarrhea (9%) Decreased appetite (6%) Vomiting (6%) Constipation (6%) [1] Similarly, here is a breakdown of Ozempic side effects in clinical trials: Nausea (15.8%) Diarrhea (8.5%) Abdominal pain (7.3%) Vomiting (5%) Constipation (5%) [2] Overall, with side effects so similar, the decision between Ozempic vs Rybelsus for weight loss comes down to patient preferences