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Alciati concluded, Although Zepbound seems to be more effective for weight loss compared to the other GLP-1R agonists on the market, the problem of rebound upon withdrawal remains an unmet need in the GLP-1R agonist space, and it needs to be further investigated and mitigated. According to the results of the SURMOUNT-4 trial investigating the maintenance of Zepbounds weight loss effects in overweight and obesity patients, patients who switched from Zepbound to placebo at week 36 of the study experienced 14 per cent weight regain at week 88, and the cardiometabolic risk factors that had improved during Zepbound treatment were reversed

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Archived from the original on 15 February 2026