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The GIP component adds: Enhanced Insulin Response: Even stronger blood sugar control than GLP-1 alone Better insulin secretion timing Improved insulin sensitivity in tissues Fat Metabolism Effects: GIP receptors exist in fat tissue May influence how body stores and uses fat Potentially increases fat burning Synergistic Appetite Suppression: GIP and GLP-1 together produce greater appetite reduction More potent satiety signals Stronger overall effect This explains why tirzepatide produces 5-7% more weight loss than semaglutidethe dual action is more powerful than GLP-1 alone

Archived from the original on 1 June 2023

doi: 10.3390/life15091422 9 d'AielloA.BonanniA.VinciR.PedicinoD.SeverinoA.De VitaA.et al

Margraf RL, Erali M, Liew M, Wittwer CT: Genotyping hepatitis C virus by heteroduplex mobility analysis using temperature gradient capillary electrophoresis