It's frequently referenced alongside MOTS-c and NAD+ in research contexts, given the complementary nature of their respective pathway interactions - particularly how NNMT inhibition influences NAD+ availability in metabolic signalling studies
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Toohey JI: Vitamin B12 and methionine synthesis: A critical review
Restoring adequate B12 levels can lead to noticeable improvements in mood, energy, and cognitive function
Our experience shows that researchers often begin with a lower concentration, such as 1-2 M, and then gradually increase it to observe dose-dependent effects