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Roles of VGLUT2 and dopamine/glutamate co-transmission in selective vulnerability to dopamine neurodegeneration

Diabetes 62 , 14531463 (2013)

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With CJC-1295/Ipamorelin, you can use a larger deficit than typical without losing muscle: Moderate Deficit (Recommended): 500-750 calories below maintenance Lose 1-1.5 lbs per week Sustainable long-term Preserves muscle mass Maintains energy and performance Aggressive Deficit (Short-term): 750-1000 calories below maintenance Lose 1.5-2 lbs per week Only for 4-8 weeks at a time Requires higher protein Follow with diet break Macronutrient Breakdown Protein (Highest Priority) 0.8-1.0g per pound body weight daily This seems high, but it's critical when dieting on peptides: Preserves muscle during deficit Highest thermic effect (30% of calories burned during digestion) Most satiating macronutrient Supports elevated GH's muscle-building effects Best Protein Sources: chicken, turkey, lean beef, fish, eggs, Greek yogurt, protein powder Fats 0.3-0.4g per pound body weight Essential for hormone production Supports GH and testosterone Improves satiety Don't go below 0.3g/lb or hormones suffer Best Fat Sources: olive oil, avocado, nuts, fatty fish, egg yolks Carbohydrates Remaining calories after protein and fat Carbs are flexible adjust based on activity level and preference: Higher on training days for performance Lower on rest days to maximize fat burning Focus on whole food sources Best Carb Sources: rice, potatoes, oats, fruit, vegetables Meal Timing for Fat Loss With peptides, meal timing matters more than usual: Stop eating 2-3 hours before injection critical for maximizing GH release Don't eat after injection ruins the fasted state needed for fat burning First meal 8-12 hours after injection extends overnight fat burning into morning Consider intermittent fasting pairs excellently with peptide therapy Foods to Avoid/Limit for Maximum Fat Loss Sugar and refined carbs spike insulin, blunt GH release Alcohol significantly impairs GH secretion and fat metabolism Processed foods excess sodium causes water retention Late-night eating interferes with peptide effectiveness Exercise Strategy to Maximize Fat Loss Training while on CJC-1295/Ipamorelin produces synergistic results you can't achieve with either alone