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LCN2 can bind to siderophores and thereby lead to iron internalization via endocytosis or to the secretion of iron via endosome recycling thereby potentially enabling iron overload or iron deficiency (67)

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The classification is not a safety judgment

Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury

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But we dont yet have the robust human trials that would allow us to say this is established mainstream medicine. That distinction matters