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However, your experience may differsome patients report significant benefits after the very first treatment, while others may require multiple sessions over several weeks to achieve their desired outcomes

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Patients with certain genetic variants show stronger appetite rebound and benefit from continuous low-dose therapy, while others may succeed with structured breaks or lower maintenance doses

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In the Phase III ATTain-1 trial, Orforglipron achieved weight loss of around 1112%, though there was a notable discontinuation rate due to gastrointestinal side effects