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Alan Mathis, PharmD Candidate 2013, University of Florida College of Pharmacy The pathophysiology of type-2 diabetes is characterized by insulin resistance and beta-cell dysfunction

2014;349:g4596

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Researchers have also found that other natural antioxidants, including multiple dietary polyphenols, can beneficially impact the inflammatory response and combat symptoms in mouse models of IBD

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Patients on any oral antihyperglycemic agent in monotherapy (N=212) or on a PPAR agent in combination therapy (N=106) or not on an antihyperglycemic agent (off therapy for at least 8 weeks, N=34) were switched to monotherapy with pioglitazone (at a dose of 30 to 45 mg per day) and completed a run-in period of approximately 12 weeks in duration