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Studies revealed that there are different types of mycotoxin which are found in pollen samples such as AFB1 (aflatoxin B1), ZEN (zearalenone), OTA (ochratoxin A), T-2, and DON (deoxynivalenol) (202), but the most important and harmful mycotoxin is AFB1 both for animal and human health causing DNA and chromosomal damage (202, 203)

In the same study, these authors reported that indoxyl sulfate provokes the enhancement of ceramide levels, which is another well-recognized eryptosis-contributing factor [253]

Genetic variations: Certain glutathione S-transferase (GST) gene polymorphisms (e.g., GSTM1, GSTP1) increase autism risk and severity, especially when combined with prenatal exposures

Individuals diet, age, gender, environment, and genes had an impact on the composition of their gut microbiota (Takagi et al., 2019)

It is speculated that the analgesic effect may be related to the durian rind extract inhibiting the production and release of inflammatory factors and scavenging free radicals