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These include TNF-alpha, IL-1 beta, and IL-6, all of which drive joint destruction in inflammatory arthritis

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Damage to the tubular endothelial cells can increase leukocyte adhesion, platelet aggregation, and vasoconstriction, reduce blood flow to nephrons, and damage the glomerular barrier and the extensive network of peritubular capillaries (88)

Upala 2015