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[4] [2] Clinical trials have demonstrated substantial reductions in hemoglobin A1c (up to 2.5%) and body weight (approximately 15-22.5% depending on dose in the SURMOUNT-1 trial), making it a significant advancement in metabolic disease treatment
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Additionally, the proximity of the rectum to the urethra (particularly in women) means that prolonged constipation increases the bacterial load near the urinary opening
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The majority of people using semaglutide long-term dont experience this issue
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