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David: I guess if you look at the lifetime risk of approval for a drug, by the time you make it to phase three, you're pretty far

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Some researchers credit GLP-1s ability to reduce inflammation, which promotes cancer cell growth and spread

The companys Phase III product Rybelsus, already FDA approved for cardiovascular risk factors and type 2 diabetes, is being positioned for a label expansion to include obesity

Beyond the obesity indication, they are studying retatrutide for type 2 diabetes (TRIUMPH-2), obstructive sleep apnea (TRIUMPH-3), and cardiovascular outcomes

In laboratory settings, the combination has been studied for its dual interaction with GHRH and ghrelin pathways, with investigations focusing on receptor binding, signaling, and the modulation of hormone dynamics